杨茂君 博士

教授

1995－1999    吉林大学，学士

1999－2003    中国协和医科大学，博士

2003－2004    德国吕贝克大学，高级访问学者

2004－2008    美国西南医学中心，博士后

2008－2013     特别研究员、博导

2013- 至今  清华大学生命科学学院，教授、博导

 

●  研究兴趣、领域：

主要以结构生物学结合细胞与分子生物学和生物化学为研究手段，从事细胞感应外界信号以及细胞能量代谢相关蛋白质的结构与功能研究，并以这些生物大分子的高分辨结构为基础开展药物设计及临床应用研究。

●  代表性论文：

1. Gu et.al. The coupling mechanism of mammalian mitochondrial complex I. Nat Struct Mol Biol. 2022 Feb;29(2):172-182.

2. Wang et.al. Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science. 2021 Oct 14:eabl4546.

3. Gu et.al. Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science. 2019 Jun 14;364 (6445):1068-1075.

4. Dong et.al.  Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature. 2018 May;557(7707):674-678.

5. Guo et.al. Architecture of human mitochondrial respiratory megacomplex I₂III₂IV₂. Cell. 2017 Sep 7;170(6):1247-1257.e12..

6. Wu et.al. Structure of mammalian respiratory supercomplex I₁III₂IV₁. Cell. 2016, Dec 01; 167(6):1598-1609.e10.

7. Gu et.al. The architecture of the mammalian respirasome. Nature. 2016 Sep 21;537(7622):639-43.

8. Wang et.al. TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell. 2016 Jun 2;165(6):1454-66.

9. Ge et.al. Architecture of the Mammalian Mechanosensitive Piezo1 Channel. Nature. 2015. Nov 5;527(7576):64-9.

10. Li et.al. Structure of the eukaryotic MCM complex at 3.8 Å. Nature. 2015 Aug 13;524(7564):186-91.

11. Guo et.al. Structural basis for hijacking CBFβ and CUL5 E3 ligase complex by HIV-1 Vif. Nature, 2014 Jan 9;505(7482):229-33.

12. Feng Y et.al. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature. 2012 Nov 15;491(7424):478-82.

13. She et.al. Structural insight into brassinosteroid perception by BRI1. Nature. 2011 Jun 12;474(7352):472-6.

●  代表性荣誉：

北京市科技奖基础类二等奖

2016年度中国生命科学领域十大进展

●  联系方式：

E-mail: maojunyang@mail.tsinghua.edu.cn